G6PC2 antibody (AA 31-130)

Catalog No. ABIN1714378

This Rabbit Polyclonal antibody specifically detects G6PC2 in ELISA and WB. It exhibits reactivity toward Human.

Quick Overview for G6PC2 antibody (AA 31-130) (ABIN1714378)

Target: G6PC2 (Glucose-6-Phosphatase, Catalytic, 2 (G6PC2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This G6PC2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-G6PC2 Antibody

Binding Specificity: AA 31-130

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Glucose 6 phosphatase 2/IGRP

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for G6PC2

Target: G6PC2 (Glucose-6-Phosphatase, Catalytic, 2 (G6PC2))

Alternative Name: Glucose 6 phosphatase 2/IGRP

Background:

Synonyms: G 6 Pase 2, G 6 Pase2, G6Pase 2, G6Pase2, G6PC 2, G6pc rs, G6pcrs, Glucose 6 phosphatase 2, Glucose 6 phosphatase, catalytic, 2, Glucose 6 phosphatase, catalytic, related, Glucose 6 phosphate catalytic 2, Islet specic G6CP related protein, Islet specic glucose 6 phosphatase, Islet specic glucose 6 phosphatase catalytic subunit related protein, G6PC2_HUMAN.

Background: Glucose-6-phosphatase (G6Pase), is a multicomponent enzyme system that hydrolyzes glucose-6-phosphate in the final step of gluconeogenesis and gluconeolysis. G6Pase localizes to the endoplasmic reticulum, and while liver, kidney, and intestine are the only tissues that express the first identified isoform, G6Pase-alpha, a second form, designated G6Pase-, contributes to blood glucose homeostasis in a wider range of tissues. Islet-specific G-6-Pase catalytic subunit-related protein (IGRP), a homolog of the catalytic subunit of G6Pase, may play a role in the regulation of islet metabolism and in insulin secretion induced by metabolites. The exact catalytic acivity of IGRP is not defined. Identification of inhibitors of IGRP have potential therapeutic benefits for treatment of type 2 diabetes resulting from insulin secretion defects. Structurally, IGRP has been shown to be a glycoprotein held in the endoplasmic reticulum by nine transmembrane domains, which are then degraded in cells through the proteasome pathway generating MHC class I presented peptides.

Gene ID: 57818