Hexb Chain A (AA 451-556) antibody

Catalog No. ABIN1714559

The Rabbit Polyclonal anti- antibody has been validated for IF (cc), IF (p), ELISA, IHC (fro), IHC (p) and ICC. It is suitable to detect in samples from Human.

Quick Overview for Hexb Chain A (AA 451-556) antibody (ABIN1714559)

Target: Hexb Chain A

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Product Details

Binding Specificity: AA 451-556

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HEXB chain A

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details

Target: Hexb Chain A

Background:

Synonyms: Beta hexosaminidase beta chain, Beta hexosaminidase subunit beta, Beta N acetylhexosaminidase, Beta-hexosaminidase subunit beta chain A, Beta-N-acetylhexosaminidase subunit beta, Cervical cancer proto oncogene 7 protein, Cervical cancer proto-oncogene 7 protein, ENC 1AS, HCC 7, HCC-7, HCC7, HEX B, Hexb, HEXB_HUMAN, Hexosaminidase B beta polypeptide, Hexosaminidase B, Hexosaminidase subunit B, HexosaminidaseB, N acetyl beta glucosaminidase, N-acetyl-beta-glucosaminidase subunit beta, HEXB chain A.

Background: Hexosaminidase B is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta-hexosaminidase is composed of two subunits, alpha and beta, which are encoded by separate genes. Both beta-hexosaminidase alpha and beta subunits are members of family 20 of glycosyl hydrolases. Mutations in the alpha or beta subunit genes lead to an accumulation of GM2 ganglioside in neurons and neurodegenerative disorders termed the GM2 gangliosidoses. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). [provided by RefSeq, Jul 2008].