NMDAR3A + 3B antibody

Catalog No. ABIN1721533

This Mouse Monoclonal antibody specifically detects NMDAR3A + 3B in IP, WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for NMDAR3A + 3B antibody (ABIN1721533)

Target: NMDAR3A + 3B (GRIN3A/B) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 3A/B (GRIN3A/B))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This NMDAR3A + 3B antibody is un-conjugated

Application: Immunoprecipitation (IP), Western Blotting (WB), Immunohistochemistry (IHC)

Clone: K35-40

Product Details anti-NMDAR3A + 3B Antibody

Specificity: Reacts with human Glutamate NMDA Receptor NR3A/B Subunit. Cross-reacts with mouse and rat protein. Do not cross-react with subunits NR1 or NR2A-D.

Purification: Purified (protein G)

Immunogen: Fusion protein of NR3A aa sequence 780-914 from the extracellular IIIIV loop.

Isotype: IgG1

Application Details

Application Notes: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
IHC(1 - 10 μg/mL) WB (1 - 10 μg/mL)

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.4.

Handling Advice: Dilute in PBS or medium that is identical to that used in the assay system.

Storage: -20 °C

Storage Comment: Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NMDAR3A + 3B

Target: NMDAR3A + 3B (GRIN3A/B) (Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 3A/B (GRIN3A/B))

Background: Two new subunits of the NMDA subtype of glutamate receptor (NMDAR) have been identified, NR3A and NR3B, with NR3B likely being the final member of the NMDAR family. These subunits show high sequence homology, although different distribution patterns: NR3B is expressed predominately in motor neurons, while NR3A is more widely distributed. When expressed in Xenopus oocytes, NR3A or NR3B assemble with NR1 to form excitatory glycine receptors that are unaffected by glutatmate.

Glutamate receptor ionotropic, NMDA 3A, GluN3A N-methyl-D-aspartate receptor subtype 3A, NMDAR3A, NR3A NMDAR-L

Gene ID: 116443

UniProt: Q8TCU5