Tacrolimus (FK506) antibody

Catalog No. ABIN1722861

Product Details

Target: Tacrolimus (FK506)

Reactivity: Chemical

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Specificity: Reacts with conjugated and non-conjugated FK-506 (Kd=10E-9M)

Purification: Purified

Immunogen: FK-506 conjugated to bovine serum albumin.

Clone: FK1

Isotype: IgM

Application Details

Application Notes: Working dilution: Optimal dilution should be determined by the end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Dilute in PBS or medium which is identical to that used in the assay system.

Storage: -20 °C

Storage Comment: Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Tacrolimus (FK506)

Alternative Name: FK-506

Target Type: Chemical

Background: FK-506 is a novel macrolide with similar, but more potent, immunosuppressant activity than cyclosporine. FK-506 is used for primary or rescue immunosuppression in patients after solid organ transplantation. Clinically relevant side effects of FK-506 administration are nephrotoxicity, neurotoxicity, diabetes mellitus, and hypertension. Most of these side effects are related to blood levels of FK-506 rather than dosage. Therefore, therapeutic drug monitoring of FK-506 is a prerequisite for therapy. The whole blood target level range aimed for in clinical practice is 3.0-20.0 ng/mL and depends on the patient's liver function, the nature of organ transplantation, and the time after transplantation.

Tacrolimus Fujimycin CAS : 109581-93-3 C44H69NO12 . H2O