APOA1 antibody

Catalog No. ABIN1724693

The Mouse Monoclonal anti-APOA1 antibody has been validated for WB and ELISA. It is suitable to detect APOA1 in samples from Human. There are 2+ publications available.

Quick Overview for APOA1 antibody (ABIN1724693)

Target: APOA1 (Apolipoprotein A-I (APOA1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This APOA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 5F4F5

Product Details anti-APOA1 Antibody

Purpose: APOA1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human APOA1 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-APOA1 antibody (ABIN1724693)

Brown, Rea, Hamon, Hixson, Boerwinkle, Clark, Sing: "The contribution of individual and pairwise combinations of SNPs in the APOA1 and APOC3 genes to interindividual HDL-C variability." in: Journal of molecular medicine (Berlin, Germany), Vol. 84, Issue 7, pp. 561-72, (2006) (PubMed).

Martina, Benso, Gigliardi, Masha, Origlia, Granata, Ghigo: "Short-term dehydroepiandrosterone treatment increases platelet cGMP production in elderly male subjects." in: Clinical endocrinology, Vol. 64, Issue 3, pp. 260-4, (2006) (PubMed).

Target Details for APOA1

Target: APOA1 (Apolipoprotein A-I (APOA1))

Alternative Name: APOA1

Background: APOA1: apolipoprotein A-I, it is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Defects in the Apolipoprotein A I gene are associated with HDL deficiency and Tangier disease. The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I. The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases.

Molecular Weight: 25 kDa

Gene ID: 335

UniProt: P02647

Pathways: Regulation of Lipid Metabolism by PPARalpha, Production of Molecular Mediator of Immune Response, Lipid Metabolism