PRDM1
Reactivity: Human
ELISA, IHC
Host: Rabbit
Polyclonal
unconjugated
Application Notes
ELISA: 1/10000
Restrictions
For Research Use only
Format
Liquid
Buffer
Ascitic fluid containing 0.03 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Jiang, Gao, Sze, Xiong, Hou: "Transcription factors Xbp-1, Blimp-1, and BSAP are involved in the regulation of plasmacytic differentiation induced by 2-methoxyestradiol in myeloma cell lines." in: International journal of hematology, Vol. 86, Issue 5, pp. 429-37, (2008) (PubMed).
Barrett, Hansoul, Nicolae, Cho, Duerr, Rioux, Brant, Silverberg, Taylor, Barmada, Bitton, Dassopoulos, Datta, Green, Griffiths, Kistner, Murtha, Regueiro, Rotter, Schumm, Steinhart, Targan, Xavier et al.: "Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. ..." in: Nature genetics, Vol. 40, Issue 8, pp. 955-62, (2008) (PubMed).
Ancelin, Lange, Hajkova, Schneider, Bannister, Kouzarides, Surani: "Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells." in: Nature cell biology, Vol. 8, Issue 6, pp. 623-30, (2006) (PubMed).
Target
PRDM1
(PR Domain Containing 1, with ZNF Domain (PRDM1))
PRDM1/Blimp1 is a repressor of beta-interferon gene expression. This action is exerted by binding to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. The transcription of this gene is increased upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported.