ESRRA antibody (N-Term)

Catalog No. ABIN1734163

This Rabbit Polyclonal antibody specifically detects ESRRA in WB and ICC. It exhibits reactivity toward Human, Mouse, Rat, Dog and Pig.

Quick Overview for ESRRA antibody (N-Term) (ABIN1734163)

Target: ESRRA (Estrogen-Related Receptor alpha (ESRRA))

Reactivity: Human, Mouse, Rat, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ESRRA antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Product Details anti-ESRRA Antibody

Binding Specificity: AA 1-50, N-Term

Specificity: Reacts with human and mouse ESRRA protein

Cross-Reactivity (Details): May cross react with rat, pig and dog (100 % sequence homology).

Purification: Purified

Immunogen: Synthetic peptide made to an N-terminal portion of the human protein (within residues 1-50). [Swiss-Prot# P11474]

Isotype: IgG

Application Details

Application Notes:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
- ICC : 1/100 - WB : 2.0 μg/mL

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, glycerol 30 % , Sodium azide 0.1 %

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Expiry Date: 6 months

Target Details for ESRRA

Target: ESRRA (Estrogen-Related Receptor alpha (ESRRA))

Alternative Name: Estrogen-Related Receptor alpha (ERR-Alpha)

Background: Estrogen-related receptor alpha (ERR alpha) is an orphan member of the superfamily of nuclear hormone receptors. It was initially isolated based on its sequence homology to the estrogen receptor but is not activated by classic estrogens. ERR alpha preferentially binds to an ERR alpha response element (ERRE) containing a single consensus half-site, TNAAGGTCA. ERR alpha can control the expression of MCAD through the NRRE-1 and thus may play an important role in regulating cellular energy balance in vivo.

Gene ID: 2101

UniProt: P11474

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha