Abeta 38/40/42 (AA 1-16), (AA 4-8) antibody

Catalog No. ABIN1742439

This anti- antibody is a Mouse Monoclonal antibody detecting in IHC and WB. Suitable for Human and Mouse. This Primary Antibody has been cited in 4+ publications.

Quick Overview for Abeta 38/40/42 (AA 1-16), (AA 4-8) antibody (ABIN1742439)

Target: Abeta 38/40/42

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Clone: NT244

Product Details

Binding Specificity: AA 1-16, AA 4-8

Specificity: Specific for Abeta 38, 40, 42.

Immunogen: Synthetic peptide (aa 1-16) of abeta peptides 38, 40, 42 coupled to key-hole limpet hemocyanin via an added C-terminal cysteine residue. Epitope aa 4-8

Isotype: IgG2b

Application Details

Application Notes: WB: 1:500 up to 1:1000 (ECL detection), ICC: 1:500, IHC: 1:500 up to 1:1000, ,

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: For reconstitution add 100µl H2O to get a 1mg/ml solution in PBS.

Buffer: PBS. Azide was added before lyophilization.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze! Antibodies should be stored at +4°C when still lyophilized.

Storage: -20 °C

Storage Comment: Reconstitute and aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized.

References

Porcellotti, Fanelli, Fracassi, Sepe, Cecconi, Bernardi, Cimini, Cerù, Moreno: "Oxidative Stress during the Progression of β-Amyloid Pathology in the Neocortex of the Tg2576 Mouse Model of Alzheimer's Disease." in: Oxidative medicine and cellular longevity, Vol. 2015, pp. 967203, (2015) (PubMed).

Reinert, Martens, Huettenrauch, Kolbow, Lannfelt, Ingelsson, Paetau, Verkkoniemi-Ahola, Bayer, Wirths: "Aβ38 in the brains of patients with sporadic and familial Alzheimer's disease and transgenic mouse models." in: Journal of Alzheimer's disease : JAD, Vol. 39, Issue 4, pp. 871-81, (2014) (PubMed).

Wirths, Hillmann, Pradier, Härtig, Bayer: "Oligomeric pyroglutamate amyloid-β is present in microglia and a subfraction of vessels in patients with Alzheimer's disease: implications for immunotherapy." in: Journal of Alzheimer's disease : JAD, Vol. 35, Issue 4, pp. 741-9, (2013) (PubMed).

Venkataramani, Wirths, Budka, Härtig, Kovacs, Bayer: "Antibody 9D5 recognizes oligomeric pyroglutamate amyloid-β in a fraction of amyloid-β deposits in Alzheimer's disease without cross-reactivity with other protein aggregates." in: Journal of Alzheimer's disease : JAD, Vol. 29, Issue 2, pp. 361-71, (2012) (PubMed).

Target Details

Target: Abeta 38/40/42