ABCA1 antibody

Catalog No. ABIN1819884

The Rat Monoclonal anti-ABCA1 antibody (Clone 5A1-1422) (ABIN1819884) specifically detects ABCA1 in WB, IF and FACS. The antibody is reactive with Mouse samples.

Quick Overview for ABCA1 antibody (ABIN1819884)

Target: ABCA1 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This ABCA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: 5A1-1422

Product Details anti-ABCA1 Antibody

Specificity: Recognizes murine adenosine triphosphate (ATP) Binding cassette transporter 1 (ABCA1). The ABC transporters are a large family of conserved proteins that transport a wide variety of molecules across cellular membranes. ABCA1 is a member of the ABC-A sub-family, which acts as a lipid translocator. The molecule was originally identified as a scavenger receptor on macrophages and research shows that ABCA1 also plays a major role in cholesterol metabolism. ABCA1 may play an important role in protecting against cardiovascular disease. Mutations in ABCA1 gene have been associated with Tangiers disease, a genetic disorder of lipid metabolism, and familial high density lipoprotein (HDL) deficiency.

Purification: Protein G purified

Immunogen: ABCA1 transfected HeLa cells.

Isotype: IgG2a

Application Details

Application Notes: Approved: Flo (1:10 - 1:200), IF, WB

Comment:

Target Species of Antibody: Mouse

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: 4°C or -20°C, Avoid freeze-thaw cycles.

Target Details for ABCA1

Target: ABCA1 (ATP-Binding Cassette, Sub-Family A (ABC1), Member 1 (ABCA1))

Alternative Name: ABCA1

Background: Name/Gene ID: ABCA1
Subfamily: ATP-binding cassette - ABCA/ABC1
Family: Transporter

Synonyms: ABCA1, ABC-1, ABC1, CERP, HDLDT1, Tangier disease, ATP-binding cassette 1, Td, Membrane-bound, TGD

Gene ID: 19

UniProt: O95477

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Lipid Metabolism by PPARalpha, Lipid Metabolism