Clusterin antibody

Catalog No. ABIN187541

The Mouse Monoclonal anti-Clusterin antibody has been validated for WB, IP, IF and IHC (fro). It is suitable to detect Clusterin in samples from Human.

Quick Overview for Clusterin antibody (ABIN187541)

Target: Clusterin (CLU)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Clusterin antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: CLI-9

Product Details anti-Clusterin Antibody

Specificity: Recognizes human clusterin. Species Reactivity: Human. Others not tested.

Purity: 95 % as determined by SDS-PAGE.

Immunogen: Purified human clusterin (TRPM-2).

Isotype: IgG1

Application Details

Application Notes: Immunohistochemistry: Frozen sections. Immunoprecipitation Immunocytochemistry Western blot: Use at approximately a 1:2,000 dilution. The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 100 µg of liquid purified monoclonal antibody at 1 mg/mL in PBS containing 0.02% sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for Clusterin

Target: Clusterin (CLU)

Alternative Name: Apolipoprotein J (Clusterin)

Background: Clusterin is the first identified extracellular mammalian chaperone and appears to be implicated in such diverse processes as sperm maturation, regulation of complement activation, programmed cell death, tissue remodeling and lipid transport. Increases in clusterin mRNA and protein have been consistently detected in apoptotic cell death paradigms, establishing clusterin gene expression as a prominent marker of apoptotic cell loss. A dual role has been shown for clusterin in that cells can be protected from damage and dead cells can be more easily removed after some types of cellular damage.

Pathways: Apoptosis, Negative Regulation of intrinsic apoptotic Signaling