CCNDBP1 antibody (N-Term)

Catalog No. ABIN1881181

This Rabbit Polyclonal antibody specifically detects CCNDBP1 in WB. It exhibits reactivity toward Human and has been mentioned in 5+ publications.

Quick Overview for CCNDBP1 antibody (N-Term) (ABIN1881181)

Target: CCNDBP1 (Cyclin D-Type Binding-Protein 1 (CCNDBP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCNDBP1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB40537

Product Details anti-CCNDBP1 Antibody

Binding Specificity: AA 21-49, N-Term

Predicted Reactivity: Pr

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CCNDBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-49 amino acids from the N-terminal region of human CCNDBP1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CCNDBP1 antibody (ABIN1881181)

Lee, Yeom, Lee, Kang, Park: "A novel senescence-evasion mechanism involving Grap2 and Cyclin D interacting protein inactivation by Ras associated with diabetes in cancer cells under doxorubicin treatment." in: Cancer research, Vol. 70, Issue 11, pp. 4357-65, (2010) (PubMed).

Seto, Ikushima, Suzuki, Sato, Fukai, Yuki, Miyazawa, Miyazono, Ishitani, Nureki: "Crystallization and preliminary X-ray diffraction analysis of GCIP/HHM transcriptional regulator." in: Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 65, Issue Pt 1, pp. 21-4, (2009) (PubMed).

Ikushima, Komuro, Isogaya, Shinozaki, Hellman, Miyazawa, Miyazono: "An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signalling." in: The EMBO journal, Vol. 27, Issue 22, pp. 2955-65, (2008) (PubMed).

Chen, Su, Jin, Chang, Chang: "Immunohistochemical expression of GCIP in breast carcinoma: relationship with tumour grade, disease-free survival, mucinous differentiation and response to chemotherapy." in: Histopathology, Vol. 53, Issue 5, pp. 554-60, (2008) (PubMed).

Chang, Chen, Chen, Su, Chang, Chang: "Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells." in: Oncogene, Vol. 27, Issue 3, pp. 332-8, (2008) (PubMed).

Target Details for CCNDBP1

Target: CCNDBP1 (Cyclin D-Type Binding-Protein 1 (CCNDBP1))

Alternative Name: CCNDBP1

Background: This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq].

Molecular Weight: 40262

NCBI Accession: NP_036274

UniProt: O95273