Hemoglobin, epsilon 1 (HBe1) (AA 55-83) antibody

Catalog No. ABIN1881403

This Rabbit Polyclonal antibody specifically detects in WB, IHC (p) and FACS. It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for Hemoglobin, epsilon 1 (HBe1) (AA 55-83) antibody (ABIN1881403)

Target: Hemoglobin, epsilon 1 (HBe1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: RB41552

Product Details

Binding Specificity: AA 55-83

Predicted Reactivity: Rb

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HBE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the Central region of human HBE1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. WB: 1:8000. IHC-P-Leica: 1:500. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References

Wang, Wang, Ma, Nie, Ju, Liu, Deng, Yao, Gui, Li, Guo, Ma, Tan, Zhao: "Heterochromatin Protein 1γ Is a Novel Epigenetic Repressor of Human Embryonic ϵ-Globin Gene Expression." in: The Journal of biological chemistry, Vol. 292, Issue 12, pp. 4811-4817, (2017) (PubMed).

Tachavanich, Viprakasit, Chinchang, Glomglao, Pung-Amritt, Tanphaichitr: "Clinical and hematological phenotype of homozygous hemoglobin E: revisit of a benign condition with hidden reproductive risk." in: The Southeast Asian journal of tropical medicine and public health, Vol. 40, Issue 2, pp. 306-16, (2009) (PubMed).

Das, Sengupta: "HbE genotypes and fertility: a study on a Tibeto-Burmese population in Upper Assam, India." in: Annals of human biology, Vol. 35, Issue 4, pp. 422-31, (2008) (PubMed).

Target Details

Target: Hemoglobin, epsilon 1 (HBe1)

Alternative Name: HBE1

Background: The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin) constitute the embryonic hemoglobin Hb Gower I, two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon - G-gamma - A-gamma - delta - beta-3'

Molecular Weight: 16203

NCBI Accession: NP_005321

UniProt: P02100