HPS5 antibody (N-Term)

Catalog No. ABIN1881436

This Rabbit Polyclonal antibody specifically detects HPS5 in WB. It exhibits reactivity toward Human and has been mentioned in 5+ publications.

Quick Overview for HPS5 antibody (N-Term) (ABIN1881436)

Target: HPS5 (Hermansky-Pudlak Syndrome 5 (HPS5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HPS5 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB42226

Product Details anti-HPS5 Antibody

Binding Specificity: AA 88-116, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HPS5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-116 amino acids from the N-terminal region of human HPS5.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-HPS5 antibody (ABIN1881436)

Helip-Wooley, Westbroek, Dorward, Koshoffer, Huizing, Boissy, Gahl: "Improper trafficking of melanocyte-specific proteins in Hermansky-Pudlak syndrome type-5." in: The Journal of investigative dermatology, Vol. 127, Issue 6, pp. 1471-8, (2007) (PubMed).

Huizing, Parkes, Helip-Wooley, White, Gahl: "Platelet alpha granules in BLOC-2 and BLOC-3 subtypes of Hermansky-Pudlak syndrome." in: Platelets, Vol. 18, Issue 2, pp. 150-7, (2007) (PubMed).

Matsuoka, Ballif, Smogorzewska, McDonald, Hurov, Luo, Bakalarski, Zhao, Solimini, Lerenthal, Shiloh, Gygi, Elledge: "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." in: Science (New York, N.Y.), Vol. 316, Issue 5828, pp. 1160-6, (2007) (PubMed).

Huizing, Hess, Dorward, Claassen, Helip-Wooley, Kleta, Kaiser-Kupfer, White, Gahl: "Cellular, molecular and clinical characterization of patients with Hermansky-Pudlak syndrome type 5." in: Traffic (Copenhagen, Denmark), Vol. 5, Issue 9, pp. 711-22, (2004) (PubMed).

Di Pietro, Falcón-Pérez, DellAngelica: "Characterization of BLOC-2, a complex containing the Hermansky-Pudlak syndrome proteins HPS3, HPS5 and HPS6." in: Traffic (Copenhagen, Denmark), Vol. 5, Issue 4, pp. 276-83, (2004) (PubMed).

Target Details for HPS5

Target: HPS5 (Hermansky-Pudlak Syndrome 5 (HPS5))

Alternative Name: HPS5

Background: This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. This protein interacts with Hermansky-Pudlak syndrome 6 protein and may interact with the cytoplasmic domain of integrin, alpha-3. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 5. Multiple transcript variants encoding two distinct isoforms have been identified for this gene.

Molecular Weight: 127449

NCBI Accession: NP_009147, NP_852608, NP_852609

UniProt: Q9UPZ3