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CDK4 antibody (C-Term)

Name: CDK4 antibody (C-Term)
SKU: ABIN1881714
Price: 451 USD
Availability: InStock

CDK4 Reactivity: Rat WB, IF, IHC (p) Host: Rabbit Polyclonal unconjugated

Rat Cdk4 Antibody (C-term) (ABIN1881714 and ABIN2843623) western blot analysis in rat lung tissue lysates (35 μg/lane). (CDK4 antibody (C-Term))

Immunohistochemical analysis of paraffin-embedded rat small intestine section using Rat Cdk4 Antibody (C-term) B. (CDK4 antibody (C-Term))

IHC (p)

Fluorescent image of MCF-7 cells stained with (Rat) Cdk4 Antibody (C-term) B. (CDK4 antibody (C-Term))

Immunohistochemical analysis of paraffin-embedded R. (CDK4 antibody (C-Term))

IHC (p)

4 images

(1 reference)

Catalog No. ABIN1881714

Datasheet as PDF

Target See all CDK4 Antibodies

CDK4 (Cyclin-Dependent Kinase 4 (CDK4))
Binding Specificity
16

16

14

9

9

8

5

4

4

3

2

2

2

2

2

2

2

1

1

1

1

1

1
AA 272-303, C-Term
Reactivity
112

62

50

19

7

5

4

3

2

1

1

1
Rat
Host
93

34

2

1
Rabbit
Compatible Secondaries
Clonality
94

35
Polyclonal
Conjugate
79

9

8

5

4

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This CDK4 antibody is un-conjugated
Application
107

46

32

25

18

15

14

14

13

11

6

4

2

2

1

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen

This Rat Cdk4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-303 amino acids from the C-terminal region of rat Cdk4.

Isotype

Ig Fraction

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CDK4 Reactivity: Human WB, IHC, IP, ICC Host: Rabbit Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 201-303) antibody
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anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 273-305) antibody
CDK4 Reactivity: Human WB, ELISA, IHC, IF, FACS Host: Rabbit Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 241-303) antibody
CDK4 Reactivity: Human, Mouse, Rat, Sheep WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (AA 272-303) antibody
CDK4 Reactivity: Human, Rat ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 4 (CDK4) (C-Term) antibody
CDK4 Reactivity: Human, Rat, Sheep, Pig, Dog, Cow, Rabbit, Guinea Pig, Horse WB, IHC Host: Rabbit Polyclonal unconjugated

Application Notes

IF: 1:25. WB: 1:1000. IHC-P: 1:25. IHC-P: 1:25

Restrictions

For Research Use only
Format

Liquid

Buffer

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative

Sodium azide

Precaution of Use

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage

4 °C,-20 °C

Expiry Date

6 months
Cho, Phillips, Khan, Weaver: "Cloning of the rat cyclin-dependent kinase 4 cDNA: implication in proliferation-dependent expression in rat tissues." in: Biochemical and biophysical research communications, Vol. 191, Issue 3, pp. 860-5, (1993) (PubMed).
Target

CDK4 (Cyclin-Dependent Kinase 4 (CDK4))

Alternative Name

Cdk4 (CDK4 Products)

Background

Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).

Molecular Weight

33799

NCBI Accession

NP_446045

UniProt

P35426

Pathways

Cell Division Cycle, Mitotic G1-G1/S Phases, Regulation of Cell Size