SEC31A antibody (AA 473-502)

Catalog No. ABIN1881783

Product Details anti-SEC31A Antibody

Target: SEC31A (SEC31 Homolog A (SEC31A))

Binding Specificity: AA 473-502

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SEC31A antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SEC31A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 473-502 amino acids from the Central region of human SEC31A.

Clone: RB41562

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-SEC31A antibody (ABIN1881783)

Fernández, Laguna, Monge, Montiel, Olmos, Pérez, Sánchez-Forcada: "Dendritic (phosphine)gold(I) thiolate complexes: assessment of the molecular size through PGSE NMR studies." in: Dalton transactions (Cambridge, England : 2003), Issue 3, pp. 474-80, (2009) (PubMed).

Shibata, Suzuki, Kakiuchi, Inuzuka, Yoshida, Mizuno, Maki: "Identification of Alix-type and Non-Alix-type ALG-2-binding sites in human phospholipid scramblase 3: differential binding to an alternatively spliced isoform and amino acid-substituted mutants." in: The Journal of biological chemistry, Vol. 283, Issue 15, pp. 9623-32, (2008) (PubMed).

Townley, Feng, Schmidt, Carter, Porter, Verkade, Stephens: "Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development." in: Journal of cell science, Vol. 121, Issue Pt 18, pp. 3025-34, (2008) (PubMed).

Target Details for SEC31A

Target: SEC31A (SEC31 Homolog A (SEC31A))

Alternative Name: SEC31A (SEC31A Products)

Background: The protein encoded by this gene is similar to yeast Sec31 protein. Yeast Sec31 protein is known to be a component of the COPII protein complex which is responsible for vesicle budding from endoplasmic reticulum (ER). This protein was found to colocalize with SEC13, one of the other components of COPII , in the subcellular structures corresponding to the vesicle transport function. An immunodepletion experiment confirmed that this protein is required for ER-Golgi transport. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].

Molecular Weight: 133015

NCBI Accession: NP_001070674, NP_001070675, NP_001070676, NP_001177978, NP_055748, NP_057295

UniProt: O94979

Pathways: ER-Nucleus Signaling