SMAD6 antibody (C-Term)
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- Target See all SMAD6 Antibodies
- SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))
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Binding Specificity
- AA 357-386, C-Term
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Reactivity
- Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SMAD6 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogen
- This SMAD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 357-386 amino acids from the C-terminal region of human SMAD6.
- Clone
- RB41931
- Isotype
- Ig Fraction
- Top Product
- Discover our top product SMAD6 Primary Antibody
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- Application Notes
- WB: 1:1000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Expiry Date
- 6 months
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Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis." in: Hepatology (Baltimore, Md.), Vol. 52, Issue 4, pp. 1266-73, (2010) (PubMed).
: "Downregulation of SMAD2, 4 and 6 mRNA and TGFbeta receptor I mRNA in lesional and non-lesional psoriatic skin." in: Acta dermato-venereologica, Vol. 89, Issue 4, pp. 351-6, (2009) (PubMed).
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Defective bone morphogenic protein signaling underlies hepcidin deficiency in HFE hereditary hemochromatosis." in: Hepatology (Baltimore, Md.), Vol. 52, Issue 4, pp. 1266-73, (2010) (PubMed).
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- Target
- SMAD6 (SMAD, Mothers Against DPP Homolog 6 (SMAD6))
- Alternative Name
- SMAD6 (SMAD6 Products)
- Background
- The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.
- Molecular Weight
- 53497
- NCBI Accession
- NP_001136333, NP_005576
- UniProt
- O43541
- Pathways
- Chromatin Binding
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