This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This UBR7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 100-128 amino acids from the N-terminal region of human UBR7.
UBR7
Reactivity: Human, Mouse, Rat
WB, IF (p), IHC (p)
Host: Rabbit
Polyclonal
unconjugated
Application Notes
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Lee, Pal, Tasaki, Roy, Jiang, An, Banerjee, Kwon: "Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 1, pp. 100-5, (2008) (PubMed).
Kiechl, Werner, Knoflach, Furtner, Willeit, Schett: "The osteoprotegerin/RANK/RANKL system: a bone key to vascular disease." in: Expert review of cardiovascular therapy, Vol. 4, Issue 6, pp. 801-11, (2006) (PubMed).
Target
UBR7
(Ubiquitin Protein Ligase E3 Component N-Recognin 7 (UBR7))
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific amino-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation (By similarity).