MTM1 antibody (N-Term)

Catalog No. ABIN1882103

The Rabbit Polyclonal anti-MTM1 antibody has been validated for WB and IHC (p). It is suitable to detect MTM1 in samples from Human. There are 6+ publications available.

Quick Overview for MTM1 antibody (N-Term) (ABIN1882103)

Target: MTM1 (Myotubularin 1 (MTM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MTM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB0722

Product Details anti-MTM1 Antibody

Binding Specificity: AA 1-30, N-Term

Predicted Reactivity: B

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This MTM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MTM1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:50~100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-MTM1 antibody (ABIN1882103)

Jian, Cheng, Jiang, Deng, Hu, Zhang: "A cDNA-based random RNA interference library for functional genetic screens in embryonic stem cells." in: Stem cells (Dayton, Ohio), Vol. 25, Issue 8, pp. 1904-12, (2007) (PubMed).

Nandurkar, Layton, Laporte, Selan, Corcoran, Caldwell, Mochizuki, Majerus, Mitchell: "Identification of myotubularin as the lipid phosphatase catalytic subunit associated with the 3-phosphatase adapter protein, 3-PAP." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 15, pp. 8660-5, (2003) (PubMed).

Biancalana, Caron, Gallati, Baas, Kress, Novelli, DApice, Lagier-Tourenne, Buj-Bello, Romero, Mandel: "Characterisation of mutations in 77 patients with X-linked myotubular myopathy, including a family with a very mild phenotype." in: Human genetics, Vol. 112, Issue 2, pp. 135-42, (2003) (PubMed).

Herman, Kopacz, Zhao, Mills, Metzenberg, Das: "Characterization of mutations in fifty North American patients with X-linked myotubular myopathy." in: Human mutation, Vol. 19, Issue 2, pp. 114-21, (2002) (PubMed).

Wishart, Dixon: "PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease." in: Trends in cell biology, Vol. 12, Issue 12, pp. 579-85, (2002) (PubMed).

Sutton, Winer, Norman, Liechti-Gallati, MacDonald: "Limb girdle and facial weakness in female carriers of X-linked myotubular myopathy mutations." in: Neurology, Vol. 57, Issue 5, pp. 900-2, (2001) (PubMed).

Target Details for MTM1

Target: MTM1 (Myotubularin 1 (MTM1))

Alternative Name: MTM1

Background: MTM1 is a member of a protein family that encodes tyrosine phosphatases. Myotubularin is required for muscle cell differentiation and mutations in MTM1 have been identified as being responsible for X-linked myotubular myopathy. MTM1 is a potent phosphatidylinositol 3-phosphate phosphatase (PI(3)P). Mutations in the MTM1 gene that cause human myotubular myopathy dramatically reduce the ability of the phosphatase to dephosphorylate PI(3)P. The findings provided evidence that myotubularin exerts its effects during myogenesis by regulating the cellular levels of the inositol lipid PI(3)P.

Molecular Weight: 69932

NCBI Accession: NP_000243

UniProt: Q13496

Pathways: Inositol Metabolic Process, Skeletal Muscle Fiber Development