TK2 antibody (N-Term)

Catalog No. ABIN1882141

This Rabbit Polyclonal antibody specifically detects TK2 in WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for TK2 antibody (N-Term) (ABIN1882141)

Target: TK2 (Thymidine Kinase 2, Mitochondrial (TK2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Application: Western Blotting (WB)

Clone: RB5434

Product Details anti-TK2 Antibody

Binding Specificity: AA 8-38, N-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Thymidine Kinase 2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-38 amino acids from the N-terminal region of human Thymidine Kinase 2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for TK2

Target: TK2 (Thymidine Kinase 2, Mitochondrial (TK2))

Background: Thymidine kinase-2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, and also phosphorylates antiviral and anticancer nucleoside analogs. Both recombinant and native forms of the enzyme have broad substrate specificity and complex kinetics, suggesting that it may play a role in the activation of chemotherapeutic nucleoside analogs. The highest levels of expression are observed in testis and ovary. The main supply of deoxyribonucleotides (dNTPs) for mitochondrial DNA synthesis comes from the salvage pathway initiated by deoxyguanosine kinase (DGK) and TK2. The association of mitochondrial DNA depletion with mutations in the genes encoding these 2 kinases suggests that the salvage pathway enzymes are involved in the maintenance of balanced mitochondrial dNTP pools.

Molecular Weight: 31005

NCBI Accession: NP_001166114, NP_001166115, NP_001258864, NP_004605

UniProt: O00142

Pathways: Mitotic G1-G1/S Phases