STK3 antibody (AA 228-252)

Catalog No. ABIN1882187

The Rabbit Polyclonal anti-STK3 antibody has been validated for WB. It is suitable to detect STK3 in samples from Human and Zebrafish (Danio rerio).

Quick Overview for STK3 antibody (AA 228-252) (ABIN1882187)

Target: STK3 (serine/threonine Kinase 3 (STK3))

Reactivity: Human, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STK3 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB47395

Product Details anti-STK3 Antibody

Binding Specificity: AA 228-252

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DANRE stk3(36kDa subunit) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 228-252 amino acids from the Central region of DANRE stk3(36kDa subunit).

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for STK3

Target: STK3 (serine/threonine Kinase 3 (STK3))

Alternative Name: stk3

Background: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein stk3/mst2 and stk4/mst1, in complex with its regulatory protein sav1, phosphorylates and activates lats1/2 in complex with its regulatory protein mob1, which in turn phosphorylates and inactivates yap1 oncoprotein and wwtr1/taz. Phosphorylation of yap1 by lats2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (By similarity).

Molecular Weight: 56081

UniProt: Q7ZUQ3

Pathways: Tube Formation