ACE2 antibody (AA 1-270)

Catalog No. ABIN1882201

This Mouse Monoclonal antibody specifically detects ACE2 in WB. It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for ACE2 antibody (AA 1-270) (ABIN1882201)

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ACE2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: 881CT16-4-4

Product Details anti-ACE2 Antibody

Binding Specificity: AA 1-270

Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: Purified His-tagged ACE2 protein was used to produced this monoclonal antibody.

Isotype: IgM

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ACE2 antibody (ABIN1882201)

Itoyama, Keicho, Hijikata, Quy, Phi, Long, Ha, Ban, Matsushita, Yanai, Kirikae, Kirikae, Kuratsuji, Sasazuki: "Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene: lack of association with SARS in the Vietnamese population." in: American journal of medical genetics. Part A, Vol. 136, Issue 1, pp. 52-7, (2005) (PubMed).

Douglas, OBryan, Hedger, Lee, Yarski, Smith, Lew: "The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis." in: Endocrinology, Vol. 145, Issue 10, pp. 4703-11, (2004) (PubMed).

Tipnis, Hooper, Hyde, Karran, Christie, Turner: "A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase." in: The Journal of biological chemistry, Vol. 275, Issue 43, pp. 33238-43, (2000) (PubMed).

Target Details for ACE2

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Background: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.

Molecular Weight: 92463

NCBI Accession: NP_068576

UniProt: Q9BYF1

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour