The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.This gene encodes a member of the E2 ubiquitin-conjugating enzyme family.The encoded protein shares 100% sequence identity with the mouse counterpart.This gene is ubiquitously expressed, with high expression seen in adult muscle.Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq]