FKBP4 antibody (AA 1-177)

Catalog No. ABIN1885705

This Rabbit Polyclonal antibody specifically detects FKBP4 in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for FKBP4 antibody (AA 1-177) (ABIN1885705)

Target: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FKBP4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-FKBP4 Antibody

Binding Specificity: AA 1-177

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 177 of FKBP52

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.500
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 20 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for FKBP4

Target: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Alternative Name: FKBP52

Background: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking.This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin.It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506.It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes.This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase.It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors.This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines.Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy.The human genome contains several non-transcribed pseudogenes similar to this gene.[provided by RefSeq]

Molecular Weight: 52 kDa

Gene ID: 2288

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway