Exportin 2 antibody (AA 222-439)

Catalog No. ABIN1886219

The Rabbit Polyclonal anti-Exportin 2 antibody has been validated for WB, IF and IHC. It is suitable to detect Exportin 2 in samples from Human.

Quick Overview for Exportin 2 antibody (AA 222-439) (ABIN1886219)

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Exportin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Product Details anti-Exportin 2 Antibody

Binding Specificity: AA 222-439

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 222 and 439 of CSE1L

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.500
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for Exportin 2

Target: Exportin 2 (CSE1L) (CSE1 Chromosome Segregation 1-Like (CSE1L))

Alternative Name: CSE1L

Background: Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer.Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex.After translocation, RanGTP binds importin-beta and displaces importin-alpha.Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind.The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1.In addition, the encoded protein may play a role both in apoptosis and in cell proliferation.[provided by RefSeq]

Molecular Weight: 110 kDa

Gene ID: 1434

NCBI Accession: NP_001307, NM_001316

Pathways: Protein targeting to Nucleus