Haptoglobin antibody (AA 70-286)

Catalog No. ABIN1886626

This Rabbit Polyclonal antibody specifically detects Haptoglobin in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for Haptoglobin antibody (AA 70-286) (ABIN1886626)

Target: Haptoglobin (HP)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Haptoglobin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Haptoglobin Antibody

Binding Specificity: AA 70-286

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 70 and 286 of Human HP

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for Haptoglobin

Target: Haptoglobin (HP)

Alternative Name: Haptoglobin

Background: This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin.Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin.Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia.This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria.A similar duplicated gene is located next to this gene on chromosome 16.Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq]

Molecular Weight: 38 kDa

Gene ID: 3240

NCBI Accession: NM_001126102, NP_001119574

Pathways: Transition Metal Ion Homeostasis