CCR5 antibody (AA 6-20)

Catalog No. ABIN1886891

The Rabbit Polyclonal anti-CCR5 antibody has been validated for WB, ELISA and IHC. It is suitable to detect CCR5 in samples from Human.

Quick Overview for CCR5 antibody (AA 6-20) (ABIN1886891)

Target: CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCR5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-CCR5 Antibody

Binding Specificity: AA 6-20

Purification: Purified by DEAE column

Immunogen: Peptide corresponding to amino acids 6 to 20 of human CCR5.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for CCR5

Target: CCR5 (Chemokine (C-C Motif) Receptor 5 (CCR5))

Alternative Name: CCR5

Background: Human immunodeficiency virus (HIV) and related virus require coreceptors, in addition to CD4, to infect target cells.Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors.Among them, CCR5 (CC-CKR-5) is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains fusion and entry of human white blood cells.CCR5 is required for the infection by HIV-1, HIV-2, and SIV.The beta-chemokines RANTES, MIP-alpha and MIP-beta are the ligands for CCR5 and prevent infection by M-tropic HIV-1.CXC5 associates with the surface CD4-gp120 of HIV complex and leads to membrane fusion and virus entry of target cells.The amino-terminal domain and the extracellular loops of CCR5 serve as HIV biding sites.CCR5 messenger RNA is expressed in lymphoid organs and monocytes.

Molecular Weight: 40 kDa

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Regulation of Cell Size