SIVA1 antibody (N-Term)

Catalog No. ABIN1888008

This anti-SIVA1 antibody is a Rabbit Polyclonal antibody detecting SIVA1 in WB and ELISA. Suitable for Human and Mouse.

Quick Overview for SIVA1 antibody (N-Term) (ABIN1888008)

Target: SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIVA1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SIVA1 Antibody

Binding Specificity: N-Term

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the amino terminus of human SIVA.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for SIVA1

Target: SIVA1 (SIVA1, Apoptosis-Inducing Factor (SIVA1))

Alternative Name: SIVA

Background: SIVA plays an important role in the apoptotic pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily.SIVA is a small cysteine-rich protein with a unique N-terminal amphipathic helical region, a death domain homology region (DDHR) and a C-terminal cysteine-rich B-box-like or zinc-finger-like structure.The DDHR domain binds to CD27 and induces apoptosis in T cells through a caspase-dependent mitochondrial pathway.SIVA inhibits BCL2L1 isoform Bcl-xL anti-apoptotic activity and inhibits activation of NFkappa-B and promotes T-cell receptor-mediated apoptosis.SIVA represents a potential therapeutic target for the treatment of neuronal cell death diseases.
Synonyms: SIVA1, apoptosis-inducing factor, CD27-binding protein, CD27BP, SIVA-1, SIVA-2

NCBI Accession: NP_068355

Pathways: Positive Regulation of Endopeptidase Activity