ING4 antibody (C-Term)

Catalog No. ABIN1944775

This Rabbit Polyclonal antibody specifically detects ING4 in WB and IHC (p). It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for ING4 antibody (C-Term) (ABIN1944775)

Target: ING4 (Inhibitor of Growth Family, Member 4 (ING4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ING4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB47839

Product Details anti-ING4 Antibody

Binding Specificity: AA 162-195, C-Term

Predicted Reactivity: B, C, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ING4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 162-195 amino acids from the C-terminal region of human ING4.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ING4 antibody (ABIN1944775)

Raho, Miranda, Tamborini, Pierotti, Greco: "Detection of novel mRNA splice variants of human ING4 tumor suppressor gene." in: Oncogene, Vol. 26, Issue 36, pp. 5247-57, (2007) (PubMed).

Shiseki, Nagashima, Pedeux, Kitahama-Shiseki, Miura, Okamura, Onogi, Higashimoto, Appella, Yokota, Harris: "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity." in: Cancer research, Vol. 63, Issue 10, pp. 2373-8, (2003) (PubMed).

Target Details for ING4

Target: ING4 (Inhibitor of Growth Family, Member 4 (ING4))

Alternative Name: ING4

Background: Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).

Molecular Weight: 28530

Gene ID: 51147

UniProt: Q9UNL4