HEXIM1 antibody

Catalog No. ABIN1944936

This anti-HEXIM1 antibody is a Rabbit Polyclonal antibody detecting HEXIM1 in WB and IF. Suitable for Human, Mouse and Rat. This Primary Antibody has been cited in 3+ publications.

Quick Overview for HEXIM1 antibody (ABIN1944936)

Target: HEXIM1 (Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HEXIM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-HEXIM1 Antibody

Isotype: IgG

Application Details

Application Notes: IF: 1:100. WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Storage: 4 °C,-20 °C

References for anti-HEXIM1 antibody (ABIN1944936)

Wittmann, Wang, Montano: "Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors." in: Cancer research, Vol. 63, Issue 16, pp. 5151-8, (2003) (PubMed).

Ouchida, Kusuhara, Shimizu, Hisada, Makino, Morimoto, Handa, Ohsuzu, Tanaka: "Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 8, Issue 2, pp. 95-107, (2003) (PubMed).

Yik, Chen, Nishimura, Jennings, Link, Zhou: "Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA." in: Molecular cell, Vol. 12, Issue 4, pp. 971-82, (2003) (PubMed).

Target Details for HEXIM1

Target: HEXIM1 (Hexamethylene Bis-Acetamide Inducible 1 (HEXIM1))

Alternative Name: HEXIM1

Background: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.

Molecular Weight: 40623 Da

Gene ID: 10614

UniProt: O94992