BCR antibody (Tyr177)
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- Target See all BCR Antibodies
- BCR (Breakpoint Cluster Region (BCR))
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Binding Specificity
- Tyr177
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This BCR antibody is un-conjugated
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Specificity
- This antibody AP02709PU detects endogenous levels of total Bcr protein.
- Purification
- Immunoaffinity Chromatography using epitope-specific immunogen.
- Immunogen
- The antiserum was produced against synthesized non-phosphopeptide derived from human Bcr around the phosphorylation site of tyrosine 177 (P-F-Yp-V-N).
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anti-Breakpoint Cluster Region (BCR) (AA 139-280) antibody
BCR Reactivity: Human WB, ELISA, FACS Host: Mouse Monoclonal 1E11G12 unconjugated
anti-Breakpoint Cluster Region (BCR) (AA 182-280) antibodyBCR Reactivity: Human WB, ELISA, IF, PLA Host: Mouse Monoclonal 2E5 unconjugated
anti-Breakpoint Cluster Region (BCR) (pTyr360) antibodyBCR Reactivity: Human, Mouse, Rat WB, ELISA, IHC, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Breakpoint Cluster Region (BCR) (pTyr177) antibodyBCR Reactivity: Human, Mouse WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Breakpoint Cluster Region (BCR) (AA 1-300) antibodyBCR Reactivity: Human WB, IHC Host: Rabbit Polyclonal unconjugated
anti-Breakpoint Cluster Region (BCR) (N-Term) antibodyBCR Reactivity: Human, Mouse WB, ELISA, IF, ICC Host: Rabbit Polyclonal unconjugated
anti-Breakpoint Cluster Region (BCR) (AA 1-1076) antibodyBCR Reactivity: Human WB, PLA Host: Rabbit Polyclonal unconjugated
anti-Breakpoint Cluster Region (BCR) (AA 331-380), (pTyr360) antibodyBCR Reactivity: Human, Mouse WB, ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
anti-Breakpoint Cluster Region (BCR) (pTyr177) antibodyBCR Reactivity: Human WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
anti-Breakpoint Cluster Region (BCR) (pTyr360) antibodyBCR Reactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
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- Application Notes
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Western blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- -20 °C
- Storage Comment
- Store the antibody (in aliquots) at -20 °C.
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- Target
- BCR (Breakpoint Cluster Region (BCR))
- Alternative Name
- BCR (BCR Products)
- Background
- The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.Synonyms: BCR1, Breakpoint cluster region protein, D22S11, NY-REN-26, Renal carcinoma antigen NY-REN-26
- Gene ID
- 613
- NCBI Accession
- NP_004318
- UniProt
- P11274
- Pathways
- Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling
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