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BCR antibody (Tyr177)

The Rabbit Polyclonal anti-BCR antibody has been validated for WB and IF. It is suitable to detect BCR in samples from Human and Mouse.
Catalog No. ABIN197420

Quick Overview for BCR antibody (Tyr177) (ABIN197420)

Target

See all BCR Antibodies
BCR (Breakpoint Cluster Region (BCR))

Reactivity

  • 98
  • 55
  • 26
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Human, Mouse

Host

  • 93
  • 4
  • 4
Rabbit

Clonality

  • 96
  • 5
Polyclonal

Conjugate

  • 61
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This BCR antibody is un-conjugated

Application

  • 72
  • 38
  • 34
  • 27
  • 26
  • 26
  • 18
  • 15
  • 14
  • 11
  • 6
  • 4
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF)
  • Binding Specificity

    • 30
    • 16
    • 8
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Tyr177

    Specificity

    This antibody AP02709PU detects endogenous levels of total Bcr protein.

    Purification

    Immunoaffinity Chromatography using epitope-specific immunogen.

    Immunogen

    The antiserum was produced against synthesized non-phosphopeptide derived from human Bcr around the phosphorylation site of tyrosine 177 (P-F-Yp-V-N).
  • Application Notes

    Western blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Restrictions

    For Research Use only
  • Concentration

    1.0 mg/mL

    Buffer

    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Avoid repeated freezing and thawing.

    Storage

    -20 °C

    Storage Comment

    Store the antibody (in aliquots) at -20 °C.
  • Target

    BCR (Breakpoint Cluster Region (BCR))

    Alternative Name

    BCR

    Background

    The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.Synonyms: BCR1, Breakpoint cluster region protein, D22S11, NY-REN-26, Renal carcinoma antigen NY-REN-26

    Gene ID

    613

    NCBI Accession

    NP_004318

    UniProt

    P11274

    Pathways

    Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling
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