ITGA6 antibody

Catalog No. ABIN206770

Product Details anti-ITGA6 Antibody

Target: ITGA6 (Integrin, alpha 6 (ITGA6))

Reactivity: Human, Mouse, Dog, Pig, Sheep, Cynomolgus

Host: Rat

Clonality: Monoclonal

Conjugate: This ITGA6 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoprecipitation (IP)

Specificity: Recognizes the CD49f-antigen, (VLA-6 alpha-chain). CD49f can form distinct complexes with either the CD29-antigen (VLA beta-chain), resulting in the VLA-6 (alpha-6 beta-1) complex, which is expressed on human platelets, or with the beta-4 integrin resulting in the alpha-6 beta-4 complex which is expressed on various human epithelial cells. Reacts with platelets, megakaryocytes, T lymphocytes and common Acute Lymphoblastic Leukemia cells (alpha-6 beta-1). In immunohistology this Reacts with epithelial cells of a variety of tissues, peripheral nerves, microvascular endothelial cells, placenta cyto- and syncytiotrophoblasts. Platelet VLA-6 functions as a laminin receptor. This clone has been reported to inhibit platelet adhesion to laminin.

Purification: Protein G purified

Immunogen: BALB/c mouse mammary tumor cells.

Type of Immunogen: Cells

Isotype: IgG2a

Application Details

Application Notes: Approved: Flo, IHC, IHC-Fr, IP

Usage: Flow Cytometry: Use 10 μL of the suggested working dilution to label 10^6 platelets in 100 μL. Method sheets are available on request.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS,  pH 7.4, 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for ITGA6

Target: ITGA6 (Integrin, alpha 6 (ITGA6))

Alternative Name: ITGA6/Integrin alpha 6/CD49f (ITGA6 Products)

Background: Name/Gene ID: ITGA6
Family: Integrin

Synonyms: ITGA6, CD49f, CD49f antigen, Integrin alpha6B, Integrin, alpha 6, Integrin alpha-6 precursor, VLA-6, Integrin alpha-6, ITGA6B

Gene ID: 3655

Pathways: CXCR4-mediated Signaling Events, Brown Fat Cell Differentiation, Integrin Complex