CD81 antibody

Catalog No. ABIN212888

The Hamster Monoclonal anti-CD81 antibody has been validated for FACS. It is suitable to detect CD81 in samples from Mouse.

Quick Overview for CD81 antibody (ABIN212888)

Target: CD81

Reactivity: Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This CD81 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: Eat2

Product Details anti-CD81 Antibody

Specificity: Reacts with the extracellular loops of murine CD81 (TAPA-1) molecule. As a member of the tetraspanin superfamily of cell-surface proteins, CD81 has been linked to the control of cell proliferation, adhesion and motility. CD81 is expressed in higher levels on resting murine B cells than on resting T cells and is functionally active on B cells as it induces homotypic adhesion of B lymphocytes. Unlike human CD81, which is expressed equally on all thymocytes, murine CD81 is upregulated on CD4+CD8+ thymocytes, then down-regulated again on mature single-positive thymocytes. Murine dendritic cells, splenic macrophages and non-killer cells all express very high levels of CD81. CD81 has also been involved in the induction of IL-4 secretion from T cells during Th2 immune responses. It has been reported that CD81 expression can also be induced in mature T cells upon activation. This anti-CD81 mAb has been shown to decrease the proliferation of LPS stimulated CD81+/+ B cells to levels similar to that of CD81-/- B cells.

Purification: Protein G purified

Immunogen:

Type of Immunogen: Native protein

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Target Species of Antibody: Mouse

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for short term applications. For long term storage, aliquot and store at -20°C.

Target Details for CD81

Target: CD81

Alternative Name: CD81

Background: Name/Gene ID: CD81
Family: Tetraspan

Synonyms: CD81, CD81 antigen, CD81 Molecule, CVID6, S5.7, TAPA1, TAPA-1, Tetraspanin-28, TSPAN28, Tspan-28

Gene ID: 975

UniProt: P60033

Pathways: Inositol Metabolic Process, Hepatitis C