ANKRD11 antibody (PE)

Catalog No. ABIN2170178

The Rabbit Polyclonal anti-ANKRD11 antibody has been validated for WB. It is suitable to detect ANKRD11 in samples from Human, Mouse and Rat.

Quick Overview for ANKRD11 antibody (PE) (ABIN2170178)

Target: ANKRD11 (Ankyrin Repeat Domain 11 (ANKRD11))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ANKRD11 antibody is conjugated to PE

Application: Western Blotting (WB)

Product Details anti-ANKRD11 Antibody (PE)

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ANKRD11

Isotype: IgG

Application Details

Application Notes: FCM: (1:20-100)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Target Details for ANKRD11

Target: ANKRD11 (Ankyrin Repeat Domain 11 (ANKRD11))

Alternative Name: Ankrd11

Background:

Synonyms: ANCO 1, ANCO1, Ankyrin repeat containing cofactor 1, Ankyrin repeat domain 11, Ankyrin repeat domain containing protein 11, LZ16, T13.

Background: Ankyrin is a membrane protein that mediates the attachment of the erythrocyte membrane skeleton to the plasma membrane and interacts with CD44 and inositol triphosphate. It contains three functional domains: a conserved N-terminal ankyrin repeat domain (ARD(consisting of 2224 tandem repeats of 33 amino acids), a spectrin binding domain and a variably sized C-terminal regulatory domain. The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops. It has been studied using multiple sequence alignment to determine which conserved amino acid residues are critical for folding and stability. Ankyrin-repeat proteins have been associated with a number of human diseases, most notably, the cell cycle inhibitor p16 is associated with cancer and the Notch protein is a key component of cell signaling pathways whose intracellular repeat domain is disrupted in mutations that give rise to the neurological disorder known as CADASIL.

Gene ID: 29123