PCGF1 antibody (PE)

Catalog No. ABIN2178330

This anti-PCGF1 antibody is a Rabbit Polyclonal antibody detecting PCGF1 in WB. Suitable for Human, Mouse and Rat.

Quick Overview for PCGF1 antibody (PE) (ABIN2178330)

Target: PCGF1 (Polycomb Group Ring Finger 1 (PCGF1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCGF1 antibody is conjugated to PE

Application: Western Blotting (WB)

Product Details anti-PCGF1 Antibody (PE)

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PCGF1

Isotype: IgG

Application Details

Application Notes: FCM: (1:20-100)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Target Details for PCGF1

Target: PCGF1 (Polycomb Group Ring Finger 1 (PCGF1))

Alternative Name: Pcgf1

Background:

Synonyms: PCGF1_HUMAN, PCGF1, Nervous system Polycomb-1, NSPc1, Polycomb group RING finger protein 1, RING finger protein 68, RNF68.

Background: PCGF1 is a component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. It represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). PCGF1 als promotes cell cycle progression and also enhances cell proliferation, thus it may have a positive role in tumor cell growth.