FERMT3 antibody (AA 401-500) (Cy5.5)

Catalog No. ABIN2179990

This Rabbit Polyclonal antibody specifically detects FERMT3 in IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for FERMT3 antibody (AA 401-500) (Cy5.5) (ABIN2179990)

Target: FERMT3 (Fermitin Family Member 3 (FERMT3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FERMT3 antibody is conjugated to Cy5.5

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-FERMT3 Antibody (Cy5.5)

Binding Specificity: AA 401-500

Predicted Reactivity: Human,Mouse,Rat,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human URP2

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FERMT3

Target: FERMT3 (Fermitin Family Member 3 (FERMT3))

Alternative Name: Urp2

Background:

Synonyms: Fermitin family homolog 3, Fermitin family member 3, FERMT3, Kind3, Kindlin 3, Kindlin-3, Kindlin3, MGC10966, MIG 2, MIG2 like protein, MIG2-like protein, MIG2B, Unc 112 related protein 2, Unc-112-related protein 2, UNC112C, URP2_HUMAN, URP2SF.

Background: Kindlin-3 is a 667 amino acid protein that localizes to both the cell membrane and the cytoplasm and contains one PH domain and one FERM domain. Expressed at high levels in lymph node tissue and at lower levels in spleen, thymus, stomach, placenta, lung, testis and small intestine, Kindlin-3 is thought to be involved in cell adhesion events and may play a role in apoptosis. Kindlin-3 is overexpressed in B-cell malignancies, suggesting that, via its ability to affect cell adhesion, Kindlin-3 may participate in tumor transformation and metastasis. Two isforms of Kindlin-3, designated short and long, exist due to alternative splicing events.