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CD31 antibody

This Rat Monoclonal antibody specifically detects CD31 in FACS, IF and IP. It exhibits reactivity toward Mouseand has been mentioned in 1 publication.
Catalog No. ABIN2191753

Quick Overview for CD31 antibody (ABIN2191753)

Target

See all CD31 (PECAM1) Antibodies
CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))

Reactivity

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Mouse

Host

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Rat

Clonality

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Monoclonal

Conjugate

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This CD31 antibody is un-conjugated

Application

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Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone

MEC7-46
  • Sterility

    0.2 μm filtered
  • Application Notes

    For immunohistochemistry and flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Positive Mouse t-end.1 cells control Negative L929 cells (Fibroblasts) control 1

    Restrictions

    For Research Use only
  • Buffer

    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C

    Storage Comment

    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
  • Xu, Zhang, Davison, Hu: "Circulating progenitor cells regenerate endothelium of vein graft atherosclerosis, which is diminished in ApoE-deficient mice." in: Circulation research, Vol. 93, Issue 8, pp. e76-86, (2003) (PubMed).

  • Target

    CD31 (PECAM1) (Platelet/endothelial Cell Adhesion Molecule (PECAM1))

    Alternative Name

    Pecam-1

    Background

    The monoclonal antibody MEC7.46 recognizes the mouse form of the platelet-endothelial cell adhesion molecule (PECAM)-1 (CD31). PECAM-1 is a member of the immunoglobulin superfamily. This heavily glycosylated protein is found in the entire vascular endothelium of adult mice and functions in mediating cellular adhesion by heterophilic and homophilic mechanisms. PECAM-1 is detected within the lymphopoietic islands in the spleen of newborn (day 12) and in the bone marrow of adult mice. Capillary endothelial cells of adult mice also express PECAM-1. The reactivity of the monoclonal antibody MEC7.46 is restricted to the isoform of the molecule that is selectively expressed by endothelial cells. The antibody precipitates a 130 kDa molecule present on the membrane of endothelial cells of all mouse blood vessels both in normal, inflamed and tumor tissues. The antigen is predominantly present at the lateral borders of endothelial cells as described for human PECAM-1. Staining of MEC7.46 can be seen on capillaries, veins, arteries and liver sinusoids. Aliases CD31, platelet-endothelial cell adhesion molecule-1 Immunogen Mouse t.end.1 cells (polyoma middle T (PmT)-transformed EC)

    Pathways

    Regulation of Actin Filament Polymerization
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