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Complement Factor H antibody

This Mouse Monoclonal antibody specifically detects Complement Factor H in WB, FACS and IA. It exhibits reactivity toward Mouse.
Catalog No. ABIN2191858

Quick Overview for Complement Factor H antibody (ABIN2191858)

Target

See all Complement Factor H (CFH) Antibodies
Complement Factor H (CFH)

Reactivity

  • 79
  • 15
  • 13
  • 3
  • 2
Mouse

Host

  • 64
  • 32
  • 3
  • 2
Mouse

Clonality

  • 60
  • 40
  • 1
Monoclonal

Conjugate

  • 64
  • 12
  • 7
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
This Complement Factor H antibody is un-conjugated

Application

  • 78
  • 49
  • 32
  • 32
  • 26
  • 17
  • 13
  • 6
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Flow Cytometry (FACS), Immunoassay (IA)

Clone

1A2
  • Cross-Reactivity (Details)

    Cross reactivity: (Yes/No) Rat : Yes

    Sterility

    0.2 μm filtered

    Isotype

    IgG1
  • Application Notes

    For immunohistology and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

    Restrictions

    For Research Use only
  • Buffer

    PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C

    Storage Comment

    Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

    Expiry Date

    12 months
  • Target

    Complement Factor H (CFH)

    Alternative Name

    Factor H

    Background

    Monoclonal antibody 1A2 recognizes mouse complement factor H (CFH). CFH is the first regulatory protein of the alternative pathway of the complement system. There are three pathways of complement activation, classical, alternative, and lectin activation pathway. These pathways converge to form C3/C5 convertases that generate C3a, C3b,C5a, and C5b, each with substantial biologic activity. Complement regulators are necessary to prevent the injudicious production of these mediators and potential injury to self-tissue. The plasma proteins CFH, C4-binding protein and the cell membrane proteins complement receptor 1 (CR1, CD35), decay-accelerating factor (CD55), and membrane co-factor protein (CD46) all are members of the regulators of complement activation family. These proteins have natural affinity for C3b and/or C4b, which confers on them the ability to accelerate the intrinsic decay of C3/C5 convertases and/or act as co-factor for the cleavage and inactivation (i) of C3b and C4b by complement factor I (CFI). Genetic human analyses reveals a clear association of CFH with different human diseases. These include diseases of the kidney, the atypical form of Hemolytic Uremic Syndrome (aHUS) and membranoproliferative glomerulonephritis (MPGN). Furthermore, CFH is associated with age-related macular degeneration (AMD), a disease of the eye. Immunogen Mouse factor H-human IgG fusion protein

    Pathways

    Complement System, Cellular Response to Molecule of Bacterial Origin
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