LRG1 antibody

Catalog No. ABIN2191876

This Mouse Monoclonal antibody specifically detects LRG1 in WB and IA. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for LRG1 antibody (ABIN2191876)

Target: LRG1 (Leucine-Rich alpha-2 Glycoprotein 1 (LRG1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This LRG1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoassay (IA)

Clone: 2F5-A2

Product Details anti-LRG1 Antibody

Sterility: 0.2 μm filtered

Application Details

Application Notes: and determine their own optimal dilutions. The typical starting working dilution is 1:50.

Restrictions: For Research Use only

Handling

Buffer: PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.

Expiry Date: 12 months

References for anti-LRG1 antibody (ABIN2191876)

Codina, Vanasse, Kelekar, Vezys, Jemmerson: "Cytochrome c-induced lymphocyte death from the outside in: inhibition by serum leucine-rich alpha-2-glycoprotein-1." in: Apoptosis : an international journal on programmed cell death, Vol. 15, Issue 2, pp. 139-52, (2010) (PubMed).

Target Details for LRG1

Target: LRG1 (Leucine-Rich alpha-2 Glycoprotein 1 (LRG1))

Alternative Name: Leucine-Rich alpha-2-Glycoprotein

Background: The monoclonal antibody recognizes leucine-rich alpha-2-glycoprotein (LRG), a member of the leucine- rich repeat family. LRG is a plasma protein of approximately 50 kDa. LRG consists of 312 amino acids. It has 1 galactosamine and 4 glucosamine oliogosacharides attached and has 2 intrachain disulfide bonds. Leucine comprises 66 of the 312 amino acids, and LRG contains at least eight 24-amino acid leucine-rich repeats. The consensus of these residues, termed leucine-rich repeats (LRR), has been identified as an LRR-containing domain. The primary function of LRRs is to provide versatile structural framework of the formation of protein-protein interactions. LRG is expressed during granulocyte differentiation. Although several family members of the leucine-rich repeat family have been shown to be involved in signal transduction, protein-protein interaction, or cell adhesion and development, a function for LRG remains elusive. LRG has been reported as a biomarker for certain diseases including microbial infections and cancer. LRG can be detected in human neutrophils and progenitor cells, but not in peripheral blood mononuclear cells. The monoclonal antibody 2F5.A2 can be used for immuno purification of human LRG. Aliases Leucine-rich alpha-2-glycoprotein, LRG Immunogen Human LRG, covalently coupled to hemocyanin using glutaraldehyde

Pathways: Brown Fat Cell Differentiation