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ITGB1 antibody (Integrin beta 1) (PE) Primary Antibody

ITGB1 Reactivity: Human, Dog, Pig FACS Host: Mouse Monoclonal MEM-101A PE
Catalog No. ABIN238444
$429.00
Plus shipping costs $45.00
100 tests
local_shipping Shipping to: United States
Available
  • Target
    ITGB1
    Reactivity
    • 245
    • 99
    • 83
    • 16
    • 11
    • 10
    • 10
    • 7
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Dog, Pig
    Host
    • 154
    • 103
    • 19
    • 7
    • 2
    • 1
    Mouse
    Clonality
    • 143
    • 138
    • 1
    Monoclonal
    Conjugate
    • 122
    • 29
    • 26
    • 20
    • 11
    • 10
    • 9
    • 9
    • 6
    • 6
    • 6
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ITGB1 antibody is conjugated to PE
    Application
    • 135
    • 134
    • 78
    • 59
    • 44
    • 32
    • 30
    • 27
    • 26
    • 20
    • 13
    • 7
    • 5
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS)
    Purification
    Size-Exclusion Chromatography
    Immunogen
    Raji Burkitt's lymphoma cell line
    Clone
    MEM-101A
    Isotype
    IgG1
  • Application Notes
    Suitable for Flow Cytometry analysis of human blood cells using 20 m l reagent / 100 m l of whole blood or 10^6 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 15 mM Sodium Azide as preservative and 0.2 % (w/v) high-grade BSA (Protease free) as stabilizer
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C
    Storage Comment
    Store the antibody in the dark at 2-8 °C. Do Not Freeze! Avoid prolonged exposure to light.
    Shelf Life: one year from despatch.
    Expiry Date
    12 months
  • Target
    ITGB1
    Alternative Name
    CD29 / Integrin beta-1 (ITGB1 Antibody Abstract)
    Synonyms
    cd29, fnrb, gpiia, itgb1, mdf2, msk12, vla-beta, vlab, CD29, 4633401G24Rik, AA409975, AA960159, ENSMUSG00000051907, Fnrb, Gm9863, gpIIa, FNRB, GPIIA, MDF2, MSK12, VLA-BETA, VLAB, integrin subunit beta 1 S homeolog, integrin subunit beta 1, integrin beta 1 (fibronectin receptor beta), itgb1.S, ITGB1, Itgb1
    Background
    CD29 (beta1 integrin subunit, GPIIa) forms non-covalently linked heterodimers with at least 6 dibberent alpha chains (alpha1-alpha6, CD49a-f) determining the binding properties of beta1 (VLA) integrins. These integrins mediate cell adhesion to collagen, fibronectin, laminin and other extracellular matrix (ECM) components. This interaction hinders cell death, whereas disruption of anchorage to ECM leads to apoptosis. Decreased expression of most beta1 integrins correlates with acquiring multidrug resistance of tumour cells during selection in presence of antitumour drug. In platelets, translocation of intracellular pool of beta1 integrins to the plasma membrane following thrombin stimulation. These integrins are also up-regulated in leukocytes during emigration and extravascular migration and appear to be critically involved in regulating the immune cell trafficking from blood to tissue, as well as in regulating tissue damage and disease symptoms related to inflammatory bowel disease. Through a beta1 integrin-dependent mechanism, fibronectin and type I collagen enhance cytokine secretion of human airway smooth muscle in response to IL-1beta.Synonyms: FNRB, Fibronectin receptor subunit beta, ITGB1, Integrin VLA-4 subunit beta, MDF2, MSK12
    UniProt
    P05556
    Pathways
    Cell-Cell Junction Organization, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex, SARS-CoV-2 Protein Interactome
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