KHDRBS1 antibody

Catalog No. ABIN2462221

This Rabbit Polyclonal antibody specifically detects KHDRBS1 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for KHDRBS1 antibody (ABIN2462221)

Target: KHDRBS1 (KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KHDRBS1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-KHDRBS1 Antibody

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human KHDRBS1.

Application Details

Application Notes: KHDRBS1 antibody can be used for detection of KHDRBS1 by ELISA at 1:12500. KHDRBS1 antibody can be used for detection of KHDRBS1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store KHDRBS1 antibody at -20 °C.

Target Details for KHDRBS1

Target: KHDRBS1 (KH Domain Containing, RNA Binding, Signal Transduction Associated 1 (KHDRBS1))

Alternative Name: KHDRBS1

Background: KHDRBS1 recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, KHDRBS1 functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain-containing proteins. KHDRBS1 play a role in G2-M progression in the cell cycle. It represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. KHDRBS1 also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export.

Molecular Weight: 48 kDa

Gene ID: 10657

NCBI Accession: NP_006550

UniProt: Q07666

Pathways: NF-kappaB Signaling, Neurotrophin Signaling Pathway, Autophagy