Inhibin alpha antibody (truncated)

Catalog No. ABIN2464073

The Mouse Monoclonal anti-Inhibin alpha antibody has been validated for WB, IHC and ELISA. It is suitable to detect Inhibin alpha in samples from Human.

Quick Overview for Inhibin alpha antibody (truncated) (ABIN2464073)

Target: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Inhibin alpha antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 4A2A9-4A2F7-4A2F2

Product Details anti-Inhibin alpha Antibody

Binding Specificity: truncated

Purification: Antibody is purified by protein A affinity chromatography.

Immunogen: Ni-NTA purified truncated recombinant INHA expressed in E. Coli strain BL21 (DE3).

Isotype: IgG1

Application Details

Application Notes: Western Blot:1:500 - 1:1,000
IHC(P):1:1,000 - 1:2,000
ELISA:Propose dilution 1:10,000
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Buffer: Purified antibody in PBS containing 0.03 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: -20 °C

Storage Comment: INHA(Inhibin alpha) monoclonal antibody can be stored at -20 °C, stable for one year.

Target Details for Inhibin alpha

Target: Inhibin alpha (INHA) (Inhibin, alpha (INHA))

Alternative Name: INHA

Background: INHA(A-inhibin subunit precursor, inhibin alpha subunit ),also called inhibin(alpha) ,which is located on chromosome 2q33-q36. Inhibin is a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). Inhibin comprises of two subunits,Inhibin A and B. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa cell tumors and can therefore be used as a marker for primary as well as recurrent disease. In addition to their role in endocrine feedback in the reproductive sytem, inhibins subserve local regulatory roles in numerous extragonadal tissues, including brain, adrenal,bone marrow, placenta, and most notably anterior pituitary. Inhibin alpha subunit gene expression is down regulated in human prostate cancer, suggesting a tumor suppressive role.

Gene ID: 3623

UniProt: P05111

Pathways: Peptide Hormone Metabolism, Hormone Activity, Negative Regulation of Hormone Secretion