PDE9A antibody (Internal Region)

Catalog No. ABIN2469457

This Rabbit Polyclonal antibody specifically detects PDE9A in IHC. It exhibits reactivity toward Human, Dog, Monkey and Gibbon.

Quick Overview for PDE9A antibody (Internal Region) (ABIN2469457)

Target: PDE9A (phosphodiesterase 9A (PDE9A))

Reactivity: Human, Dog, Monkey, Gibbon

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE9A antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-PDE9A Antibody

Binding Specificity: Internal Region

Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Purification: Immunoaffinity Chromatography

Immunogen: PDE9A antibody was raised against a peptide located near the internal domain of PDE9A (Human).

Application Details

Application Notes: PDE9A antibody can be used in ELISA, Western Blot, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-80 °C

Storage Comment: PDE9A antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Target Details for PDE9A

Target: PDE9A (phosphodiesterase 9A (PDE9A))

Alternative Name: PDE9A

Background: Phosphodiesterase 9A is a cGMP-specific phosphodiesterase. PDE9A activity is inhibited by zaprinast, but it is insensitive to rolipram, vinpocetine, SKF-94120, dipyridamole, and IBMX. More than 20 alternatively spliced variants have been reported (Rentero et al. 2003). PDE9A has been implicated in penile erectile dysfunction, as well as in functional disturbances in which intraneuronal signal transmission via second messengers are important in the pathophysiology (example, bipolar affective disorder). PDE9A is the only cGMP-specific PDE with significant expression in the forebrain, and as such is likely to function in NO-cGMP signaling.

Gene ID: 5152

UniProt: O76083