PDE1C antibody (C-Term)

Catalog No. ABIN2469467

The Rabbit Polyclonal anti-PDE1C antibody has been validated for IHC. It is suitable to detect PDE1C in samples from Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Bat, Hamster, Monkey, Gibbon, Gorilla and Orang-Utan.

Quick Overview for PDE1C antibody (C-Term) (ABIN2469467)

Target: PDE1C (phosphodiesterase 1C, Calmodulin-Dependent 70kDa (PDE1C))

Reactivity: Human, Mouse, Rat, Cow, Dog, Horse, Rabbit, Bat, Hamster, Monkey, Gibbon, Gorilla, Orang-Utan

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE1C antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-PDE1C Antibody

Binding Specificity: C-Term

Specificity: BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Purification: Immunoaffinity Chromatography

Immunogen: PDE1C antibody was raised against a peptide located in the C-Terminal domain of PDE1C (Human).

Application Details

Application Notes: PDE1C antibody can be used in immunohistochemistry starting at 10 μg/mL, and flow cytometry.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.1 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-80 °C

Storage Comment: PDE1C antibody should be stored long term (months) at -80 °C and short term (days) at 4 °C.

Target Details for PDE1C

Target: PDE1C (phosphodiesterase 1C, Calmodulin-Dependent 70kDa (PDE1C))

Alternative Name: PDE1C

Background: Phosphodiesterase 1C is a cAMP/cGMP dual-specific, calcium/calmodullin-dependent phosphodiesterase. PDE1C has been shown to affect vascular smooth muscle proliferation and atherosclerosis, insulin secretion regulation, spermatozoa development, and erectile dysfunction. At least five PDE1C isoforms have been reported, the expression of which are regulated in a tissue/cell-specific manner.

Gene ID: 5137

UniProt: Q14123

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma