TLX1 antibody (AA 300-330)

Catalog No. ABIN2470149

This anti-TLX1 antibody is a Rabbit Polyclonal antibody detecting TLX1 in WB and IHC. Suitable for Mouse, Human, Rat, Cow, Dog, Rabbit, Bat, Monkey, Chicken, Horse, Hamster, Gibbon and Gorilla.

Quick Overview for TLX1 antibody (AA 300-330) (ABIN2470149)

Target: TLX1 (T-Cell Leukemia Homeobox 1 (TLX1))

Reactivity: Mouse, Human, Rat, Cow, Dog, Rabbit, Bat, Monkey, Chicken, Horse, Hamster, Gibbon, Gorilla

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLX1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-TLX1 Antibody

Binding Specificity: AA 300-330

Purification: Protein G Column

Immunogen: TLX1 antibody was raised against amino acids 300 - 330 of TLX1 (Human).

Isotype: IgG

Application Details

Application Notes: TLX1 antibody can be used in ELISA, Western Blot starting at 1:500 - 1:1000, immunohistochemistry starting at 5 μg/mL, and immunofluorescence starting at 10 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, 0.2 % gelatin, 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies avoid freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: TLX1 antibody can be stored short term 4 °C. For long term storage aliquot and store at -20 °C.

Target Details for TLX1

Target: TLX1 (T-Cell Leukemia Homeobox 1 (TLX1))

Alternative Name: TLX1

Background: HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35,q24) or t(10:14)(q24,qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.

Gene ID: 3195

UniProt: P31314