CACNA1C antibody (AA 1507-1733) (PE)

Catalog No. ABIN2485661

Product Details anti-CACNA1C Antibody (PE)

Target: CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))

Binding Specificity: AA 1507-1733

Reactivity: Rabbit

Host: Mouse

Clonality: Monoclonal

Conjugate: This CACNA1C antibody is conjugated to PE

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Antibody Array (AA)

Specificity: Detects ~240 kDa (varies with cell background due to glycosylation).

Cross-Reactivity: Hamster, Human, Mouse, Rat

Purification: Protein G Purified

Immunogen: Fusion protein amino acids 1507-1733 (intracellular carboxyl terminus) of rabbit Cav1.2

Clone: S57

Isotype: IgG1

Application Details

Application Notes:

• WB (1:1000)
• IHC (1:1000)
• ICC/IF (1:100)
• IP (1:200)
• optimal dilutions for assays should be determined by the user.

Comment:

1 μg/ml of ABIN2485661 was sufficient for detection of Cav1.2 in 10 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Conjugated antibodies should be stored at 4°C

Target Details for CACNA1C

Target: CACNA1C (Calcium Channel, Voltage-Dependent, L Type, alpha 1C Subunit (CACNA1C))

Alternative Name: Cav1.2 (CACNA1C Products)

Background: Cav1.2 is a cardiac L-type calcium channel, and is important for excitation and contraction of the heart (1). It may be associated with a variant of Long QT syndrome called Timothy's syndrome (2, 3) and also with Brugada syndrome. Some references also suggest it is related to bipolar disease as well (3).

Gene ID: 100101555

NCBI Accession: NP_001129994

UniProt: P15381

Pathways: Hormone Transport, Carbohydrate Homeostasis