CD8 alpha antibody (violetFluor™ 450)

Catalog No. ABIN2567983

This anti-CD8 alpha antibody is a Mouse Monoclonal antibody detecting CD8 alpha in FACS. Suitable for Human.

Quick Overview for CD8 alpha antibody (violetFluor™ 450) (ABIN2567983)

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD8 alpha antibody is conjugated to violetFluor™ 450

Application: Flow Cytometry (FACS)

Clone: OKT8

Product Details anti-CD8 alpha Antibody (violetFluor™ 450)

Specificity: The OKT8 monoclonal antibody specifically reacts with human CD8α molecule, a tyPEI transmembrane glycoprotein of 32-34 kDa.

Purification: The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate-buffered aqueous solution, ≤0.09 % Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Storage: 4 °C

Storage Comment: The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.

Target Details for CD8 alpha

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Alternative Name: CD8a

Background: The OKT8 monoclonal antibody specifically reacts with human CD8α molecule, a tyPEI transmembrane glycoprotein of 32-34 kDa. CD8α is a member of the Ig superfamily, expressed as a homodimer (CD8αα) or as a heterodimer (CD8αβ). CD8+ αβ T lymphocytes express both CD8αα and CD8αβ, while some T lymphocytes and the natural killer cells express only the homodimers. CD8 binds to MHC class I and influences the development and the activation of T lymphocytes.OKT8, RPA-T8, and HIT8a antibodies do not compete with each other for binding to peripheral leukocytes, meaning that that they do not recognize the same epitoPEor block each other by steric hindrance.BG Violet 450 conjugate is an alternative to the Pacific Blue, eFluor 450, or BD Horizon V450 dyes. It is excited by the violet (405 nm) laser, with a peak emission of 450nm.

Gene ID: 925

UniProt: P01732

Pathways: TCR Signaling