Valproic Acid antibody

Catalog No. ABIN5610817

This anti-Valproic Acid antibody is a Mouse Monoclonal antibody detecting Valproic Acid in EIA. Suitable for .

Quick Overview for Valproic Acid antibody (ABIN5610817)

Target: Valproic Acid

Host: Mouse

Clonality: Monoclonal

Conjugate: This Valproic Acid antibody is un-conjugated

Application: Enzyme Immunoassay (EIA)

Clone: 801

Product Details anti-Valproic Acid Antibody

Purification: Protein G chromatography

Immunogen: Valproic acid conjugated to KLH

Isotype: IgG1

Application Details

Application Notes: May be used in immunoassays to detect and quantitate valproic acid.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.2mg/mL (OD280nm)

Buffer: PBS, pH 7.4

Storage: -20 °C

Storage Comment: Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for Valproic Acid

Target: Valproic Acid

Target Type: Chemical

Background: Valproic acid, valproate sodium and divalproex belong to the group of medicines called anticonvulsants, used to control certain types of seizures in the treatment of epilepsy. Also, valproic acid relieves histone deacetylases (HDACs) dependent transcriptional repression and causes hyperacetylation of histones in cultured cells and in vivo. Valproic acid inhibits HDAC activity in vitro, most probably by binding to the catalytic centre of HDACs. Most importantly, valproic acid induces differentiation of carcinoma cells, transformed haematopoietic progenitor cells and leukaemic blasts from acute myeloid leukaemia patients. Moreover, tumour growth and metastasis formation are significantly reduced in animal experiments. Therefore, valproic acid might serve as an effective drug for cancer therapy.