Neu5Gc antibody

Catalog No. ABIN2656682

This anti- antibody is a Chicken Polyclonal antibody detecting in FACS. Suitable for Mammalian.

Quick Overview for Neu5Gc antibody (ABIN2656682)

Target: Neu5Gc

Reactivity: Mammalian

Host: Chicken

Clonality: Polyclonal

Application: Flow Cytometry (FACS)

Clone: Poly21469

Product Details

Cross-Reactivity (Details): All mammals except human

Isotype: IgY

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid, Lyophilized

Buffer: This Neu5Gc antibody is lyophilized.

Storage: -20 °C

Storage Comment: For long-term storage, store the lyophilized antibody at -20°C or -70°C. After reconstitution, store the antibody between 2°C and 8°C for up to 2 weeks. For longer term storage up to 6 months, store the reconstituted product in aliquots at -20°C.

Target Details

Target: Neu5Gc

Background: Neu5Gc (N-Glycolylneuraminic acid) is a sialic acid molecule found in most mammals but not in humans. It is derived from the most commonly expressed sialic acid, Neu5Ac, differing from it by only one oxygen atom. The gene CMAH that encodes for CMP-N-acetylneuraminic acid hydroxylase is responsible for the conversion of Neu5Ac to Neu5Gc. In humans, this gene is inactive due to a deletion mutation. As such, the human immune system sees Neu5Gc as a foreign, immunogenic molecule. Neu5Gc enters the human body primarily through dietary intake of red meat and dairy products. Neu5Gc is also incorporated, albeit to a lesser degree, into certain biopharmaceuticals, through the use of animal-derived reagents and cell lines during the manufacturing of these products. Due to its immunogenic properties, the intake and incorporation of Neu5Gc in humans causes the formation of circulating antibodies against this non-human molecule, which can lead to chronic inflammation, the exacerbation of certain diseases, and possibly reduced the efficacy of biopharmaceuticals.