BST2 antibody (Alexa Fluor 488)

Catalog No. ABIN2657400

This Rat Monoclonal antibody specifically detects BST2 in FACS. It exhibits reactivity toward Mouse.

Quick Overview for BST2 antibody (Alexa Fluor 488) (ABIN2657400)

Target: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This BST2 antibody is conjugated to Alexa Fluor 488

Application: Flow Cytometry (FACS)

Clone: 927

Product Details anti-BST2 Antibody (Alexa Fluor 488)

Purification: The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 488 under optimal conditions.

Isotype: IgG2b kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C

Target Details for BST2

Target: BST2 (Bone Marrow Stromal Cell Antigen 2 (BST2))

Alternative Name: CD317

Background: CD317, known as BST2, tetherin, HM1.2 antigen, bone marrow stromal antigen 2, or PDCA-1, is type II transmembrane glycoprotein with a molecular mass of 29-33 kD. It is predominantly expressed on Type I IFN-producing cells (IPCs) in naive mice, but is up-regulated on most cell types following stimulation with type I IFNs and IFN-gamma. It is highly expressed on terminally differentiated normal plasmacytoid dendritic cells and some tumor cells, such as multiple myeloma, renal cell carcinoma, and melanoma cells. BST2 is a recently identified, IFN-induced cellular response factor that blocks release of HIV-1 and other retroviruses from infected cells. BST2 has been found to be the natural ligand of ILT7 in human model.

Pathways: Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response