ICOS antibody (Alexa Fluor 647)

Catalog No. ABIN2657721

This Hamster Monoclonal antibody specifically detects ICOS in FACS and ICFC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ICOS antibody (Alexa Fluor 647) (ABIN2657721)

Target: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Reactivity: Human, Mouse, Rat

Host: Hamster

Clonality: Monoclonal

Conjugate: This ICOS antibody is conjugated to Alexa Fluor 647

Application: Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)

Clone: C398-4A

Product Details anti-ICOS Antibody (Alexa Fluor 647)

Cross-Reactivity: Rhesus Monkey, Pig (Porcine)

Purification: The antibody was purified by affinity chromatography, and conjugated with Alexa Fluor® 647 under optimal conditions.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from prolonged exposure to light. Do not freeze.

Storage: 4 °C

Storage Comment: The antibody solution should be stored undiluted between 2°C and 8°C

Target Details for ICOS

Target: ICOS (Inducible T-Cell Co-Stimulator (ICOS))

Alternative Name: CD278

Background: ICOS, also known as inducible costimulatory molecule and H4, is a 47-57 kD protein. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes. It is able to costimulate T cells proliferation. In addition, ICOS is involved in humoral immune responses (B cell germinal center formation). The ICOS ligand is B7h/B7RP-1 or B7-H2. ICOS stimulation has been shown to potentiate TCR-mediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development.

Pathways: Cancer Immune Checkpoints